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💊 What acepromazine is

Acepromazine is a phenothiazine tranquilizer/sedative used in dogs, cats, horses, and other animals. It’s not a painkiller and not an anesthetic by itself — it mainly causes sedation and reduced anxiety.

It works by depressing the central nervous system and blocking dopamine receptors, producing calming and muscle-relaxing effects.

🐶🐱 Common veterinary uses

Vets use acepromazine to:

Calm anxious or aggressive animals
Provide pre-anesthetic sedation before surgery or procedures
Control motion sickness or nausea related to travel
Reduce stress during grooming or veterinary visits
Help manage certain behavioral emergencies (short-term)

It’s also used in emergency settings to help control agitation.

🧪 Typical dosing (educational ranges only)

These are general ranges for understanding, not prescriptions.

Dogs

Oral: ~0.25–1 mg per lb (≈0.5–2 mg/kg)
Injectable: usually lower than oral doses

Cats

Oral: ~0.05–0.15 mg per lb (≈0.1–0.3 mg/kg)

Actual dose depends on:

Size and breed
Health status
Reason for use
Other drugs being given

Effects you’ll typically see

Within 15–60 minutes, pets may show:

Drowsiness / sleepiness
Reduced anxiety and reactivity
Lower responsiveness
Muscle relaxation
Droopy eyelids

It usually lasts 4–8 hours, though some animals stay sedated longer.

⚠️ Important risks and side effects

Acepromazine is generally safe when used by a vet, but it has important cautions.

Common side effects

Sleepiness and lethargy
Low blood pressure
Lowered body temperature
Pale gums

Less common but serious

Excessively low blood pressure (hypotension)
Collapse or extreme weakness
Slow heart rate
Breathing suppression (rare)
Paradoxical agitation (especially in some aggressive dogs)

🚨 Breed and condition cautions

Extra caution (or lower doses) in:

Dog breeds more sensitive:

Boxers
Bulldogs
Greyhounds

Medical conditions where caution is needed:

Heart disease
Liver disease
Seizure disorders
Dehydration or shock
Anemia
Clotting disorders

Acepromazine lowers blood pressure, so it’s not ideal in unstable or critically ill animals.

Important limitations

A key thing many people don’t realize:

Acepromazine does NOT relieve pain.
It only sedates. Pain control must come from other medications.

Also, animals may look calm while still feeling fear, because their body can’t react normally.

Bottom line

Acepromazine is a reliable, long-used veterinary sedative and tranquilizer that’s helpful for short-term calming and pre-anesthetic use, but it must be:

✅ properly dosed
✅ tailored to the species and breed
✅ avoided or used carefully in certain health conditions