Buy Propalin (Phenylpropanolamine)
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Propalin (Phenylpropanolamine) Syrup
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Proin Chewables
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Ships from upstate New York
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💊 What Proin and Propalin are

Both Proin® and Propalin® are brand names for phenylpropanolamine (PPA).

They are sympathomimetic drugs that work by:

• Stimulating alpha-adrenergic receptors

• Increasing tone of the urethral sphincter

• Helping keep the bladder outlet tightly closed

They are not hormones and not sedatives.

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✅ Key differences between Proin and Propalin

Proin

• Usually used in North America

• Comes as flavored chewable tablets or extended-release tablets (Proin ER)

Propalin

• More common in Europe and other countries

• Comes mainly as an oral liquid (syrup)

Despite the different brand names and forms, the active drug is the same.

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🐶 Main veterinary use

Dogs

PPA is mainly prescribed to treat:

Urethral sphincter mechanism incompetence (USMI)
This is the classic spay incontinence seen in:

• Spayed female dogs

• Especially medium to large breeds

• Usually middle-aged or older

Typical signs:

• Urine leaking during sleep

• Wet bedding

• Dribbling without awareness

PPA helps strengthen the sphincter and prevent leakage.

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🐱 Use in cats

• Used much less commonly in cats

• Occasionally used off-label for true urinary incontinence

• Cats are more sensitive to stimulant side effects

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🧪 Typical dosing (educational ranges only)

General veterinary reference ranges — NOT a prescription.

Dogs

Immediate-release PPA:

• About 1–2 mg per lb (2–4 mg/kg) per day

• Divided into 2–3 doses

Extended-release (Proin ER):

• Often once daily dosing

Liquid Propalin:

• Dosed by ml/kg according to the specific formulation strength

Actual dose is tailored by the vet.

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⏱️ How fast it works

• Can start improving urine control within hours to days

• Full effect often seen within several days

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⚠️ Common side effects

More common

• Restlessness

• Panting

• Nervousness / anxiety

• Loss of appetite

• Mild increase in heart rate

Less common but serious

• High blood pressure

• Heart rhythm problems

• Tremors

• Aggression or marked behavior changes

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🚨 Use with caution or avoid if your pet has

• Heart disease or murmurs

• High blood pressure

• Hyperthyroidism (especially in cats)

• Glaucoma

• Seizure disorders

• Prostate disease (in intact male dogs)

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Drug interactions

Be cautious combining PPA with:

• Tricyclic antidepressants

• MAO inhibitors

• Other stimulants

• Decongestants

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Proin / Propalin vs hormone therapy

PPA drugs:
✅ Non-hormonal
✅ Often first-line for spay incontinence

Hormonal options like estriol (Incurin®):
✅ Work well in many spayed females
⚠️ Can have hormonal side effects

Some dogs need both together for best results.

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🧭 Monitoring while on PPA

Vets often recommend:

• Blood pressure checks

• Monitoring heart rate and behavior

• Periodic rechecks, especially in older dogs

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Bottom line

Proin (US) and Propalin (EU and elsewhere) are essentially the same medication — phenylpropanolamine — and are highly effective for canine urinary incontinence caused by weak urethral sphincter tone, especially in spayed female dogs.

They are fast-acting and very helpful when properly dosed and monitored.

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