Phenylpropanolamine (Proin, Propalin)  
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Propalin (PhenylpropanolamineSyrup
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Phenylpropanolamine (Proin, Propalin)

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Proin general information

What is Proin used for?

Proin is used to treat urinary incontinence in spayed female dogs. Involuntary loss of urine can occur in male and female dogs at any age but particularly in spayed females. More than 20% of spayed females are affected and mid to large-sized breeds are also more prone. Proin is an effective and palatable oral treatment for long-term management of urinary incontinence in dogs and you should be able to see an improvement within a week. 

How does Proin work?

Proin contains phenylpropanolamine, a sympathomimetic alpha-adrenergic agonist that mimics the effects of nerves of the sympathetic nervous system. These nerves respond to sympathomimetic amines like catecholamine and adrenaline. Urinary incontinence is usually caused by loss of muscle tone in the urethral sphincter, which is the muscle that controls urine flow out of the bladder. Phenylpropanolamine in Proin stimulates the alpha-adrenergic receptors in the urethral muscle, which increases tone of the sphincter muscle resulting in tightening of the urethra, to preventing urine leakage. 

What does Proin contain?

Proin contains the active ingredient phenylpropanolamine (50mg/ml), used to treat urinary incontinence in dogs. 

Treating urinary incontinence with Proin

Proin contains phenylpropanolamine, used to treat urinary incontinence in dogs. Urinary incontinence is usually caused by loss of muscle tone in the urethral sphincter, which is the muscle that controls urine flow out of the bladder. Phenylpropanolamine in Proin stimulates the alpha adrenergic receptors in the urethral muscle which increases tone of the sphincter muscle resulting in tightening of the urethra to preventing urine leakage. Involuntary loss of urine can occur in male and female dogs at any age but particularly in spayed females. Proin is an effective oral treatment for long-term management of urinary incontinence in dogs. 

What are the side effects of Proin?

The most commonly reported side effects for dogs taking Proin, which mimic the results of excessive stimulation of the sympathetic nervous system include: anorexia, aggressive behaviour, restlessness, irritability, tremors, tachycardia, cardiac arrhythmia, hypertension, and urinary retention. Lethargy and loss of appetite have been reported in a dog following an overdose. 

When should Proin not be used?

You should not give Proin to your dog if they:

  • show signs of allergic reaction or hypersensitivity to phenylpropanolamine or any ingredients in Proin
  • have a pre-existing medical conditions such as heart disease, high blood pressure disease or kidney problems, glaucoma or diabetes mellitus
  • have a history of epilepsy
  • are pregnant or lactating
  • are receiving medications for cardiovascular disease or any other sympathomimetic drugs

How should Proin be given?

You should give Proin to your dog 3 times daily using the oral syringe provided. Add the correct dose of Proin to your dogs food or administer directly into your dogs mouth. The recommended dose is 1 mg/kg bodyweight which is 0.1mL per 5 kg of body weight. 

Missed dose of Proin

If you miss a dose of Proin give it to your dog as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not give a double dose. 

How should Proin be stored?

You should store your Proin between 15C and 25C in a cool dry place. 

 

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