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Acepromazine is the most common tranquilizer and central nervous system depressant given to pets. It is used to prevent anxiety associated with thunder, fireworks, vet or groomer visits, and other things your pet may fear. It is effective treatment against motion sickness and nausea associated with car or plane rides.
 
The effects typically last 6-8 hours. It is more effective to give this drug 45-60 minutes before your pet is expected to display any anxious behavior.